• Laura Fuglsang Bech, Lotte Drustrup, Louis Nygaard, Anders Skallerup, Line Dahlstrøm Christensen, Lars Vinter-Jensen, Henrik Højgaard Rasmussen, and Mette Holst.
• Department of Health Science and Technology, Aalborg University, Aalborg, Denmark laurafbech@hotmail.com.
• JPEN J Parenter Enteral Nutr. 2016 Sep 1; 40 (7): 989-94.

BackgroundTunneled, cuffed, central venous catheters, including Hickman catheters and peripherally inserted central venous catheters (PICCs), are the most commonly used venous access for home parenteral nutrition (HPN) therapy. Catheter-related bloodstream infection is the most prevalent and severe complication. This study investigated whether environmental risk factors, including smoking, catheter management by a home care nurse, colectomy with stoma, number of infusion days per week, and C-reactive protein at catheter insertion day, influenced the time to first catheter-related bloodstream infection (CRBSI).Materials And MethodsIn this 6-year (2008-2014) observational cohort study, adult patients with intestinal failure receiving HPN through either Hickman catheters or PICCs were included. Data were obtained by reviewing medical records, and the environmental risk factors were analyzed with the Cox proportional hazards model.ResultsA total of 295 catheters (Hickman catheters: n = 169 and PICCs: n = 126) inserted into 136 patients were registered. Using the PICCs, 1 additional infusion day per week showed to significantly decrease the time to first CRBSI by a factor of 2.47. Hickman catheters managed by a home care nurse had a significantly increased mean (SD) incidence of CRBSI of 1.45 (0.68) per 1000 catheter days. Hickman catheters not managed by a home care nurse had a mean (SD) incidence of 0.56 (0.24).ConclusionUsing the PICC, 1 additional infusion day per week decreased the time to first CRBSI, while having the Hickman catheter managed by a home care nurse increased the mean CRBSI incidence. No other risk factors were found.© 2015 American Society for Parenteral and Enteral Nutrition.

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