• Qian Xu, Harideep Samanapally, Pavani Nathala, Vidyulata Salunkhe, Stephen Furmanek, Meredith N Cahill, Trevor McGuffin, Tahboub Mohammad, Bradford Marsili, Jessica Petrey, Ruth Carrico, Julio Ramirez, Ozan Akca, Sean P Clifford, Siddharth Pahwa, Lynn Roser, Maiying Kong, Jiapeng Huang, and Center of Excellence for Research in Infectious Diseases (CERID) Coronavirus Study Group on behalf of the COVID-19 CardioVascular Research Group (COVID-CVRG).
• Department of Bioinformatics and Biostatistics, School of Public Health and Information Sciences, University of Louisville, Louisville, KY.
• J. Cardiothorac. Vasc. Anesth. 2021 Dec 1; 35 (12): 358135933581-3593.

ObjectiveTo analyze outcomes and risk factors of cardiovascular events in a metropolitan coronavirus disease 2019 (COVID-19) database, and to perform a subgroup analysis in African American populations to determine whether outcomes and risk factors are influenced by race.DesignRetrospective cohort analysis from March 9, 2020 to June 20, 2020.SettingPopulation-based study in Louisville, KY, USA.ParticipantsSeven hundred adult inpatients hospitalized with COVID-19.InterventionsN/A.Measurements And Main ResultsThis cohort consisted of 126 patients (18%) with cardiovascular events and 574 patients without cardiovascular events. Patients with cardiovascular events had a much higher mortality rate than those without cardiovascular events (45.2% v 8.7%, p < 0.001). There was no difference between African American and white patients regarding mortality (43.9% v 46.3%, p = 1) and length of stay for survivors (11 days v 9.5 days, p = 0.301). Multiple logistics regression analysis suggested that male, race, lower SaO2/FIO2, higher serum potassium, lower serum albumin, and number of cardiovascular comorbidities were highly associated with the occurrence of cardiovascular events in COVID-19 patients. Lower serum albumin and neoplastic and/or immune-compromised diseases were highly associated with cardiovascular events for African American COVID-19 patients. SaO2/FIO2 ratio and cardiovascular comorbidity count were significantly associated with cardiovascular events in white patients.ConclusionsCardiovascular events were prevalent and associated with worse outcomes in hospitalized patients with COVID-19. Outcomes of cardiovascular events in African American and white COVID-19 patients were similar after propensity score matching analysis. There were common and unique risk factors for cardiovascular events in African American COVID-19 patients when compared with white patients.Copyright © 2021 Elsevier Inc. All rights reserved.

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