• J Arthroplasty · Sep 2017

    Randomized Controlled Trial

    Effectiveness of Bupivacaine Liposome Injectable Suspension for Postoperative Pain Control in Total Knee Arthroplasty: A Prospective, Randomized, Double Blind, Controlled Study.

    • Jeffrey H DeClaire, Paige M Aiello, Olayinka K Warritay, and Dwight C Freeman.
    • Department of Surgery and Orthopaedic Surgery, DeClaire LaMacchia Orthopaedic Institute, Crittenton Hospital Medical Center, Rochester Hills, Michigan.
    • J Arthroplasty. 2017 Sep 1; 32 (9S): S268-S271.

    BackgroundWe compared the effectiveness of liposomal bupivacaine to ropivacaine, each as part of multimodal pain management, in total knee arthroplasty (TKA) postoperative pain control.MethodsThis prospective, double blind study randomized 96 TKA patients into a control group (periarticular injection of ropivacaine, ketorolac, morphine, and epinephrine in saline; 100cc) or an experimental group (periarticular injection of bupivacaine, ketorolac, morphine, and epinephrine in saline; 80cc plus 1.3% liposomal bupivacaine 20cc; total injection 100cc). The postoperative use of narcotics, visual analog pain scores, hours to ambulate 100 feet, and length of hospital stay were recorded.ResultsThere was no significant difference between the two groups (control N = 49, experiment N = 47) in mean narcotic use per hour, total narcotic use during hospital stay, time to ambulate 100 feet, length of hospital stay, or visual analog score for pain postoperatively.ConclusionThere is no benefit in the use of liposomal bupivacaine compared with ropivacaine for postoperative pain control in TKA.Copyright © 2017 Elsevier Inc. All rights reserved.

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