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Biol. Blood Marrow Transplant. · May 2015
Review Case ReportsManagement of relapsed multiple myeloma after autologous stem cell transplant.
- Sarah A Holstein, Paul G Richardson, Jacob P Laubach, and Philip L McCarthy.
- Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York.
- Biol. Blood Marrow Transplant. 2015 May 1; 21 (5): 793-8.
AbstractAutologous stem cell transplantation (ASCT) remains a standard of care for multiple myeloma patients who are eligible to receive high-dose therapy, recognizing that the optimal timing and integration of this approach is now under study in a number of randomized trials. Despite the improved response rates with induction therapy consisting of immunomodulatory drugs and/or proteasome inhibitors, as well as the increasing use of post-ASCT maintenance therapy, most myeloma patients relapse and die of their disease. Here we discuss the options for managing post-ASCT relapse, including the role of various salvage regimens in the setting of relapsed and refractory myeloma, salvage ASCT, and salvage allogeneic SCT. Copyright © 2015 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.
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