• Debra E Irwin, Ian Milsom, Kate Reilly, Steinar Hunskaar, Zoe Kopp, Sender Herschorn, Karin S Coyne, Con J Kelleher, Walter Artibani, and Paul Abrams.
• Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA. dirwin@email.unc.edu
• J Sex Med. 2008 Dec 1; 5 (12): 2904-10.

IntroductionThe prevalence of sexual dysfunction, including erectile dysfunction (ED), is greater in men with lower urinary tract symptoms (LUTS), including overactive bladder (OAB), than in men without LUTS.AimTo evaluate the prevalence of ED, the impact of urinary symptoms on sexual activity and sexual enjoyment, and sexual satisfaction in men with OAB.MethodsA nested case-control analysis was performed on data from a subset of men with (cases) and without (controls) OAB frequency-matched for age (5-year age strata) and country from the EPIC study. Respondents were asked about OAB symptoms (using the 2002 International Continence Society [ICS] definitions) and sexual activity. Sexually active respondents were asked about ED, sexual enjoyment, and overall satisfaction with their sex lives. Conditional logistic regression was used to assess factors associated with ED.Main Outcome MeasuresThe percentage of cases and controls reporting ED, a reduction in the frequency of sexual activity or enjoyment of sexual activity because of urinary symptoms, and overall satisfaction with their sex lives was determined for cases and controls.ResultsA total of 502 cases and 502 controls were matched for age strata and country. Significantly more cases (14%) reported reduced sexual activity because of urinary symptoms compared with controls (4%; P ConclusionsOAB, as defined by the ICS, was significantly associated with increased prevalence of ED, reduced sexual activity and sexual enjoyment because of urinary symptoms, and reduced sexual satisfaction.

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