• Byoung Seok Ye, Eun Young Jang, Seong Yoon Kim, Eun-Joo Kim, Sun Ah Park, Yunhwan Lee, Chang Hyung Hong, Seong Hye Choi, Bora Yoon, Soo Jin Yoon, Hae Ri Na, Jae-Hong Lee, Jee H Jeong, Hee Jin Kim, Duk L Na, and Sang Won Seo.
• Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
• J. Alzheimers Dis. 2016 Jan 1; 49 (2): 483-91.

Background And ObjectiveWe investigated the influence of body mass index (BMI) status at baseline and changes in BMI over a follow-up period on the development of dementia in amnestic mild cognitive impairment (aMCI) patients.MethodsThe longitudinal data of 747 aMCI patients were used to investigate the relationships among baseline BMI status, subsequent changes in BMI (median follow-up duration: 1.6 years, interquartile range: 1.0-2.3 years), and risk of progression to probable Alzheimer's disease dementia (pADD). The aMCI patients were classified into underweight, normal weight, overweight, and obese subgroups, and further categorized into increased BMI, stable BMI, and decreased BMI subgroups during follow-up using a 4% mean annual change in BMI cut-off value.ResultsCompared to the normal weight group, the underweight group had a higher risk of pADD (hazard ratio [HR]: 1.89, 95% confidence interval [CI]: 1.07-3.37) while the obese group had a lower risk (HR: 0.70, 95% CI: 0.49-0.999). After controllingfor baseline BMI status, the decreased BMI (HR: 2.29, 95% CI: 1.41-3.72) and increased BMI (HR: 3.96, 95% CI: 2.62-6.00) groups were at increased risk of progression to pADD.ConclusionsOur findings suggested that underweight at baseline was associated with a higher risk of progression to pADD, while obesity at baseline predicted a lower risk. Furthermore, significant changes in BMI during the follow-up period reflected an increased risk of progression to pADD, regardless of BMI status at baseline.

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