• Influenza Other Respi Viruses · Sep 2020

    Meta Analysis

    Seroprevalence of H7N9 infection among humans: A systematic review and meta-analysis.

    • Qiang Wang, Ke Xu, Weihua Xie, Liuqing Yang, Haiyan Chen, Naiyang Shi, Changjun Bao, Haodi Huang, Xuefeng Zhang, Yilan Liao, and Hui Jin.
    • Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.
    • Influenza Other Respi Viruses. 2020 Sep 1; 14 (5): 587-595.

    AbstractIn spring 2013, a novel avian-origin influenza A (H7N9) virus emerged in mainland China. The burden of H7N9 infection was estimated based on systematic review and meta-analysis. The systematic search for available literature was conducted using Chinese and English databases. We calculated the pooled seroprevalence of H7N9 infection and its 95% confidence interval by using Freeman-Tukey double arcsine transformation. Out of 16 890 records found using Chinese and English databases, 54 articles were included in the meta-analysis. These included studies of a total of 64 107 individuals. The pooled seroprevalence of H7N9 infection among humans was 0.122% (95% CI: 0.023, 0.275). In high-risk populations, the highest pooled seroprevalence was observed among close contacts (1.075%, 95% CI: 0.000, 4.357). The seroprevalence among general population was (0.077%, 95% CI: 0.011, 0.180). Our study discovered that asymptomatic infection of H7N9 virus did occur, even if the seroprevalence among humans was low.© 2020 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.

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