• Youngbuhm Huh, Choon Park Dong D, Geun Yeo Seung S, and Chang Cha Il.
• Department of Anatomy and Neurobiology, MRC for Reactive Oxygen Species, College of Medicine, KyungHee University, Seoul.
• Acta Otolaryngol. 2008 Jun 1; 128 (6): 648-53.

ConclusionsThe age-related increase in the production of nitric oxide (NO) suggests that this increase was related to neuron aging. Additional studies may provide information regarding aging-related changes in the central auditory system.ObjectivesAlthough NO has been associated with aging, it is unclear whether specific areas of the central auditory system are involved. We therefore assayed aging-related changes in NADPH-diaphorase (NADPH-d), a selective histochemical marker for NO, in the neurons of the central auditory system and other brain regions.Materials And MethodsThe numbers of NADPH-d-stained neurons and the area and staining density of cell bodies were examined in aged (24 months old) and younger (4 months old) Wistar rats.ResultsThe number of NADPH-d-positive neurons in the inferior colliculus was significantly increased in aged rats (p<0.05), whereas the area of NADPH-d-positive neurons in all areas did not differ significantly between aged and younger rats (p>0.05). The staining densities of NADPH-d-positive neurons in the inferior colliculus, the auditory cortex, and the visual cortex were significantly greater in aged compared with younger rats (p<0.05).

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