• Neuroscience letters · Oct 2016

    Differential patterns of regional cerebral hypometabolism according to the level of cerebral amyloid deposition in patients with amnestic mild cognitive impairment.

    • So Yeon Jeon, Dahyun Yi, Min Soo Byun, Hyo Jung Choi, Kim Hyun Jung HJ Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea., Lee Jun Ho JH Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea., Hyewon Baek, Young Min Choe, Younghwa Lee, Jong Inn Woo, and Dong Young Lee.
    • Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
    • Neurosci. Lett. 2016 Oct 6; 632: 104-8.

    AbstractAlthough amnestic mild cognitive impairment (aMCI) with high cerebral deposition of amyloid-beta proteins (Aβ) could be classified as a prodromal state of Alzheimer's disease (AD) dementia, aMCI with the absence of or very little cerebral Aβ deposition is likely related to other pathophysiological processes. Thus, the present study aimed to investigate the differential patterns of regional cerebral glucose metabolism (rCMglu) according to the level of Aβ burden in the brains of patients with aMCI. This study included 25 patients with aMCI and 33 cognitively normal (CN) elderly individuals who underwent a comprehensive clinical examination, (11)C-labelled Pittsburgh Compound B (PiB) positron emission tomography (PET) scans, and (18)F-fluorodeoxyglucose (FDG) PET scans. Based on cerebral PiB retention, the aMCI subjects were divided into low Aβ (aMCI-, n=10) and high Aβ (aMCI+, n=15) subgroups, and differences in rCMglu among the CN group and aMCI subgroups were estimated on a voxel-by-voxel basis. Compared with the CN group, rCMglu was decreased in the bilateral medial temporal regions of the aMCI- subgroup and in the medial temporal cortices as well as the right precuneus of the aMCI+ subgroup. Additionally, rCMglu was lower in the right precuneus of the aMCI+ subgroup compared with the aMCI- subgroup. The present findings indicate that, even though both aMCI subgroups were phenomenologically very similar, the patients with aMCI- exhibited a markedly different regional pattern of functional neurodegeneration compared with the aMCI+ patients. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

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