• Altuğ Ösken, Recep Hacı, Lale Dinç Asarcıklı, Mehmet Erdinç Arıkan, Tolga Onuk, Ünal DayıŞennurŞDepartment of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research ... more Hospital, Tibbiye cad. 13, Haydarpasa, Istanbul, Turkey., and Neşe Çam. less
• Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, Tibbiye cad. 13, Haydarpasa, Istanbul, Turkey. alosk@hotmail.com.
• Ir J Med Sci. 2021 Aug 1; 190 (3): 1095-1102.

BackgroundDespite the important role of some haematological parameters in tendency to thrombosis is known, their relationship with long-term stent thrombosis (ST) remains unclear.AimsThis study aimed to investigate the association between the mean platelet volume (MPV) to platelet count (PC) ratio and long-term ST and mortality in patients with ST-segment-elevation myocardial infarction (STEMI) treated successfully by primary percutaneous coronary intervention (pPCI).MethodsIn a retrospective cohort study, according to their baseline MPV/PC ratios, 3667 consecutive STEMI patients undergoing pPCI were divided into three groups: tertile 1 (T1) (n = 1222, 0.357 ≥ MPV/PC ≥ 0.043), tertile 2 (T2) (n = 1222, 0.033 < MPV/PC < 0.043) and tertile 3 (T3) (n = 1223, 0.009 ≤ MPV/PC ≤ 0.032). Patients were followed up with for 5 years, focusing on ST and all-cause mortality outcomes.ResultsPatients with T1 displayed a greater 5-year ST rate, including a 2.76-fold greater (95% confidence interval 1.68-10.33) rate than that of patients with T3, who had the lowest rates and were used as the reference group. Meanwhile, the 5-year mortality rate was similarly higher among patients with T1 by 1.72 times (95% confidence interval 1.33-2.22) relative to that among patients with T3. These significant relationships persisted even after adjustment for all confounders.ConclusionWe found that higher MPV/PC ratios were associated with long-term ST and mortality. The MPV/PC ratio may constitute both a rapid and an easily obtainable parameter for identifying reliably high-risk patients who have undergone pPCI.© 2021. Royal Academy of Medicine in Ireland.

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