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- Minlee Kim and Frank J Slack.
- Department of Molecular, Cellular and Developmental Biology, Yale University, PO Box 208103, New Haven, CT, 06511, USA. minlee.kim@yale.edu.
- J Hematol Oncol. 2014 Nov 30; 7: 84.
AbstractWhile microRNAs (miRNAs) and the KRAS oncogene are known to be dysregulated in various cancers, little is known about the role of miRNAs in the regulation of KRAS in cancer. Here we review a selection of studies published in 2014 that have contributed to our understanding of the molecular mechanisms of KRAS regulation by miRNAs and the clinical relevance of sequence variants that may interfere with functional miRNA-mediated KRAS regulation.
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