• Wei-Jian Wang, Jia-Hao Zhou, Guo-Liang He, Qiao-Lin Wu, Wei Gao, Jie-Hao Sun, and Peng-Bo Zhang.
• Department of Anesthesiology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
• J Ultrasound Med. 2017 Mar 1; 36 (3): 631-638.

ObjectivesThe purpose of this study was to investigate the correlation between flow-mediated dilatation of the brachial artery and serum endothelial biomarkers and to discuss the feasibility of sonographic evaluation of acute endothelial injury during cardiopulmonary bypass (CPB) surgery.MethodsSonography was applied to determine the percentage of change in the brachial artery size during flow-mediated dilatation. Meanwhile, the plasma concentrations of endothelial-derived biomarkers, such as endothelin 1, nitric oxide, and von Willebrand factor, were measured to monitor the changes in endothelial function. We analyzed the correlation between flow-mediated dilatation and biomarkers during the perioperative period of CPB in 27 patients.ResultsAll of the biomarkers changed dramatically, especially during the CPB period. There was a negative correlation between flow-mediated dilatation and von Willebrand factor (P = .001; R = -0.31).ConclusionsA CPB event has a substantial impact on endothelial function, and sonographic assessment of the percentage of change in the brachial artery size during flow-mediated dilatation allows early detection of acute endothelial function injury in cardiac surgery.© 2017 by the American Institute of Ultrasound in Medicine.

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