• Jun-ichi Oyama, Daisuke Nagatomo, Goro Yoshioka, Ayumu Yamasaki, Kazuhisa Kodama, Michio Sato, Hiroshi Komoda, Toshiyuki Nishikido, Aya Shiraki, and Koichi Node.
• Department of Advanced Cardiology, Saga University, Saga, Japan. Electronic address: junoyama@cc.saga-u.ac.jp.
• J Cardiol. 2016 Mar 1; 67 (3): 295-302.

BackgroundObstructive sleep apnea (OSA) is characterized by repetitive intermittent hypoxia and reoxygenation during sleep with elevated oxidative stress and promotes the development of atherosclerosis, as demonstrated by vascular dysfunction and chronic inflammation. An increased neutrophil to lymphocyte ratio (NLR) has been recognized to be a novel inflammatory biomarker for systemic inflammation.ObjectivesWe evaluated whether the NLR reflects the severity of OSA and if continuous positive airway pressure (CPAP) treatment ameliorates the endothelial function and NLR in patients with OSA.MethodsWe enrolled 95 patients with suspected OSA and 29 patients who received CPAP therapy for 3 months. We evaluated the number of endothelial progenitor cells (EPCs) and NLR, the levels of nitric oxide (NOx) and asymmetric dimethylarginine (ADMA), and the endothelial function according to the flow-mediated dilatation (FMD) before and after CPAP treatment.ResultsThe levels of apnea-hypopnea index demonstrated an inverse relationship with the FMD and a positive relationship with the NLR. Moreover, NLR is an independent factor suggested for the presence of severe OSA. CPAP therapy increased the levels of EPC and NOx and decreased the level of ADMA. CPAP treatment also improved the FMD and decreased the NLR.ConclusionsNLR and endothelial dysfunction significantly correlates with the severity of OSA and FMD and other biochemical parameters improved and NLR decreased significantly after CPAP treatment.Copyright © 2015 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

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