• Shaik Mohamed Asif, Shaik Mohamed Shamsudeen, Khalil Ibrahim Assiri, Hussain Mohammed Al Muburak, Sultan Mohammed Kaleem, Abdul Ahad Khan, and Mansoor Shariff.
• Department of Diagnostic Science and Oral Biology.
• Medicine (Baltimore). 2021 Apr 30; 100 (17): e22387e22387.

IntroductionDrug induced oral erythema multiforme a rare clinical entity which involves only the lips and oral mucosa without skin involvement. These lesions are difficult in diagnosing with other oral ulcerative lesions with similar clinical manifestations.Patient ConcernsThis article presents 2 case reports of Oral erythema multiforme in which drugs were the precipitating factor. Its etiopathogenesis, differential diagnosis and treatment modalities of the disease is discussed.DiagnosisBased on patient's complaints, drug history and clinical appearance, provisional diagnosis of drug induced erythema multiforme was considered.InterventionFor case 1, patient was instructed to discontinue usage of drug and prescribed systemic steroid (Prednisolone 10 mg/d) for a week along with germicidal drugs to prevent secondary infection. Medication was tapered to 5 mg/d after first week.For case 2, patient was instructed to discontinue the drug and systemic steroid prednisolone 20 mg /d for 1 week with tapering dose of 10 mg/d for the second week was administered.OutcomeFor case 1 and case 2 healing of the lesions were evident on third week of follow up.ConclusionMedications should be taken under medical supervision. Over the counter drugs might lead to allergic reactions like drug induced oral erythema multiforme, which is a rare variant and needs to be differentiate from other oral ulcerative lesion for prompt management and follow-up.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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