• Piao Cai, Zhu Wu, Wei Huang, Qian Niu, Ye Zhu, and Dehui Yin.
• College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan.
• Medicine (Baltimore). 2021 Apr 30; 100 (17): e25613.

BackgroundDiabetic nephropathy (DN) is one of the most common complications of diabetes and the main cause of kidney failure in developed countries. Clinically, DN is usually treated by controlling blood sugar and blood pressure. According to reports, the application of angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor antagonist can only target a certain stage of disease development. However, the application of Suoquan Pill (SQP) in traditional Chinese medicine has produced obvious clinical effects and minor side effects. It is used to treat DN and other diseases, but there is no systematic review of SQP in the treatment of diabetic nephropathy. This article reviews the effectiveness and safety of SQP in the treatment of DN.MethodsThe database sets the registration date for randomized controlled trials (RCT) to March 25, 2021. By searching the following eight Chinese and English electronic databases: Cochrane Library, Embase, PubMed, Science Net, China National Knowledge Infrastructure, China Biomedical Literature Database. Chinese scientific journal database and Wanfang database for analysis. The main results are clinical efficacy, urinary albumin excretion rate, symptom score and quality of life. Finally, Stata 15 was used for meta-analysis.ResultsThis study will provide the latest evidence for SQP in the treatment of DN in the following aspects: clinical efficacy, urinary albumin excretion rate, quality of life, symptom score.ConclusionThe results of this study will provide evidence for evaluating the effectiveness of SQP in the treatment of DN.Osf Registration Number10.17605/OSF.IO/KZ9RA.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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