• Shuai Zhang, Meiyan Song, Wei An, and Zhongyi Wang.
• Department of Anesthesiology, Harrison International Peace Hospital, Hebei Medical University, Hengshui, Hebei Province, China.
• Medicine (Baltimore). 2021 Apr 30; 100 (17): e25651e25651.

BackgroundDexamethasone has been widely used in brachial plexus block to enhance the effects of brachial plexus block. However, the clinical findings are not consistent with the dosage of dexamethasone prolonging local anesthetic nerve block. Therefore, the purpose of this study was to explore the effects of different doses of dexamethasone as local anesthetic adjuvant on brachial plexus block through network meta-analysis.MethodsWe searched PubMed, Web of Science, Cochrane Library, and Embase databases to collect all randomized controlled trials (RCTs) of different doses of dexamethasone as local anesthetic adjuvant on brachial plexus block until March 2021. Two researchers then independently screened articles, extracted data, and evaluated the quality of selected literatures. All data was processed by Stata 14.0 and WinBUGS 1.4.3.software.ResultsThe results of this meta-analysis will be submitted to a peer-reviewed journal for publication.ConclusionOur study is expected to provide high-quality evidence-based medicine advice for the effects of different doses of dexamethasone as local anesthetic adjuvant on brachial plexus block.Ethics And DisseminationEthical approval was not required for this study. The systematic review will be published in a peer-reviewed journal, presented at conferences, and shared on social media platforms.Osf Registration NumberDOI 10.17605/OSF.IO/PZ5WR.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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