• Pacing Clin Electrophysiol · Aug 2007

    Case Reports

    Brugada syndrome in the presence of coronary artery disease and parasympathomimetic drug therapy.

    • Richard F Otten, Adrian C Dusa, and Mithilesh K Das.
    • Krannert Institute of Cardiology, Indiana University School of Medicine, 1800 North Capitol Avenue, Indianapolis, IN 46202, USA.
    • Pacing Clin Electrophysiol. 2007 Aug 1; 30 (8): 1039-42.

    AbstractBrugada pattern ECG changes have been described in various disease states and drug therapies, including electrolyte abnormalities, myocardial pathology, medications, and mechanical abnormalities. Therefore, the diagnosis of Brugada syndrome cannot be made in the presence of confounding variables according to prevailing guidelines. We present a case report which illustrates two important principles regarding Brugada syndrome, the dynamic ECG manifestations and the elimination of confounding variables (in this case significant coronary artery disease and cholinergic pharmacotherapy) prior to definitive diagnosis.

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