• Raffaele Marfella, Maria Rosaria Rizzo, Mario Siniscalchi, Pasquale Paolisso, Michelangela Barbieri, Celestino Sardu, Antonella Savinelli, Nicola Angelico, Salvatore Del Gaudio, Nicolino Esposito, Pier Francesco Rambaldi, Nunzia D'Onofrio, Luigi Mansi, Ciro Mauro, Giuseppe Paolisso, and Maria Luisa Balestrieri.
• Department of Geriatrics and Metabolic Diseases Second University of Naples, Italy. Electronic address: raffaele.marfella@unina2.it.
• Int. J. Cardiol. 2013 Oct 9; 168 (4): 3954-62.

BackgroundWe examined the effects of peri-procedural intensive glycemic control during early percutaneous coronary intervention (PCI) on the number and differentiation of endothelial progenitor cells (EPCs) and myocardial salvage (MS) in hyperglycemic patients with first ST-elevation myocardial infarction (STEMI).Methods And ResultsWe conducted a randomized, prospective, open label study on 194 patients with STEMI undergoing PCI: 88 normoglycemic patients (glucose < 140 mg/dl) served as the control group. Hyperglycemic patients (glucose ≥140 mg/dl) were randomized to intensive glycemic control (IGC) for almost 24 h after PCI (n = 54; 80-140 mg/dl) or conventional glycemic control (CGC, n = 52; 180-200 mg/dl). EPC number, differentiation, and SIRT1expression were assessed immediately before, 24 h, 7, 30 and 180 days after PCI. The primary end point of the study was salvage index, measured as the proportion of initial perfusion defect (acute technetium-99m sestamibi scintigraphy, performed 5 to 7 days after STEMI) and myocardium salvaged by therapy (6 months after STEMI). Hyperglycemic patients had lower EPC number and differentiation and lower SIRT1 levels than normoglycemic patients (P < 0.01). After the insulin infusion, mean plasma glucose during peri-procedural period was greater in CGC group than in IGC group (P < 0.001). The EPC number, their capability to differentiate, and SIRT1 levels were significantly higher in IGC group than in CGC, peaking after 24 h (P < 0.01). In the IGC group, the salvage index was greater than in patients treated with CGC (P < 0.001).ConclusionsOptimal peri-procedural glycemic control, by increasing EPC number and their capability to differentiate, may improve the myocardial salvage.© 2013. Published by Elsevier Ireland Ltd. All rights reserved.

49 keywords...

hide…