• Neuroscience letters · Apr 2011

    Role of transient receptor potential ankyrin subfamily member 1 in pruritus induced by endothelin-1.

    • Jiexian Liang, Qing Ji, and Wenjin Ji.
    • Division of Anesthesiology, Department of Cardiovascular Surgery, Guangdong Institute of Cardiovascular, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
    • Neurosci. Lett. 2011 Apr 4; 492 (3): 175-8.

    AbstractNoxious cold reduces pruritus and transient receptor potential ankyrin subfamily member 1 (TRPA1), a non-selective cation channel, is known as a noxious cold-activated ion channel. Recent findings implicated the involvement of TRPA1 in pain induced by endothelin-1 (ET-1). Therefore, we evaluated its potential role in pruritus induced by ET-1. We found that ruthenium red (RR; a nonselective TRP inhibitor) and AP18 (a TRPA1 antagonist) significantly increased scratching bouts caused by ET-1, while capsazepine (a TRPV1 antagonist) and morphine showed no effects in the ET-1-induced scratching response. However, RR and capsazepine significantly reduced scratching bouts caused by histamine. Our results suggested that activation of TRPA1 could suppress itch induced by ET-1 and this is not related to pain induced by ET-1.Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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