• Brain pathology · Jul 1999

    Case Reports

    Case of the month: February 1999--54 year old man with severe muscle weakness.

    • M D Hill and J M Bilbao.
    • University of Toronto Neuropathology, St. Michael's Hospital, ON, Canada.
    • Brain Pathol. 1999 Jul 1; 9 (3): 607-8.

    AbstractA 54 year old man developed rhabdomyolysis one year after beginning treatment with a combination of lovastatin (an HMGCoA reductase inhibitor) and niacin. Muscle biopsy showed a severe necrotizing myopathy affecting both fibre types. Recovery occured gradually with cessation of medication. The spectrum of cholesterol lowering agent myopathy may include delayed cases of unusual severity.

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