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Cytokine Growth Factor Rev. · Aug 2020
ReviewThe potential of JAK/STAT pathway inhibition by ruxolitinib in the treatment of COVID-19.
- Bakiye Goker Bagca and Cigir Biray Avci.
- Department of Medical Biology, Medical Faculty, Ege University, Izmir, Turkey. Electronic address: bakiye.goker.bagca@ege.edu.tr.
- Cytokine Growth Factor Rev. 2020 Aug 1; 54: 51-62.
AbstractRuxolitinib is the first approved JAK1 and JAK2 inhibitor, and is known to interfere with the JAK / STAT signaling pathway, one of the critical cellular signaling pathways involved in the inflammatory response. This review presents an overview of SARS-CoV-2 and the COVID-19 pandemic, and then focuses on the potential efficacy of ruxolitinib in this infection. The potential targets of ruxolitinib were determined by using genetic alterations that have been reported in COVID-19 patients. The potential effectiveness of ruxolitinib is suggested by evaluating the interactions of these potential targets with ruxolitinib or JAK/STAT pathway.Copyright © 2020 Elsevier Ltd. All rights reserved.
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