• Neural Regen Res · Apr 2015

    Electrical stimulation of the vagus nerve protects against cerebral ischemic injury through an anti-infammatory mechanism.

    • Yao-Xian Xiang, Wen-Xin Wang, Zhe Xue, Lei Zhu, Sheng-Bao Wang, and Zheng-Hui Sun.
    • Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China.
    • Neural Regen Res. 2015 Apr 1; 10 (4): 576-82.

    AbstractVagus nerve stimulation exerts protective effects against ischemic brain injury; however, the underlying mechanisms remain unclear. In this study, a rat model of focal cerebral ischemia was established using the occlusion method, and the right vagus nerve was given electrical stimulation (constant current of 0.5 mA; pulse width, 0.5 ms; frequency, 20 Hz; duration, 30 seconds; every 5 minutes for a total of 60 minutes) 30 minutes, 12 hours, and 1, 2, 3, 7 and 14 days after surgery. Electrical stimulation of the vagus nerve substantially reduced infarct volume, improved neurological function, and decreased the expression levels of tumor necrosis factor-α and interleukin-6 in rats with focal cerebral ischemia. The experimental findings indicate that the neuroprotective effect of vagus nerve stimulation following cerebral ischemia may be associated with the inhibition of tumor necrosis factor-α and interleukin-6 expression.

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