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- Nicola Clementi, Roberto Ferrarese, Elena Criscuolo, Roberta Antonia Diotti, Matteo Castelli, Carolina Scagnolari, Roberto Burioni, Guido Antonelli, Massimo Clementi, and Nicasio Mancini.
- Laboratory of Microbiology and Virology, Università Vita-Salute San Raffaele, Milan, Italy.
- J. Infect. Dis. 2020 Aug 4; 222 (5): 722-725.
AbstractThe ongoing coronavirus disease 2019 pandemic has forced the clinical and scientific community to try drug repurposing of existing antiviral agents as a quick option against severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Under this scenario, interferon (IFN) β-1a, whose antiviral potential is already known, and which is a drug currently used in the clinical management of multiple sclerosis, may represent as a potential candidate. In this report, we demonstrate that IFN-β-1a was highly effective in inhibiting in vitro SARS-CoV-2 replication at clinically achievable concentration when administered after virus infection.© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
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