• Jing Shan, Lu Wang, Zhuo Li, Ying Liu, Ji-rong Gao, Yan-lei Pang, Jun-hong Li, Fu-min Pang, Xin-hui Guo, Hong-Zhi Chi, Chang-geng Zhang, and Hui Li.
• Institute of Hepatitis Research, Affiliated You'an Hospital, Capital University of Medical Sciences, Beijing 100096, China.
• Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006 Apr 1; 28 (2): 148-53.

ObjectiveTo determine whether -Taq I T/C and -Fok I C/T polymorphisms of vitamin D receptor (VDR) gene are associated with the familial aggregation of hepatitis B virus (HBV) infection.MethodsBased on a population-based case-control family design, 288 family members from 27 case families and 230 family members from 27 control families were recruited. VDR gene polymorphisms were analyzed. VDR-Taq I T/C and VDR-Fok I C/T polymorphisms were examined by polymerase chain reaction-restriction fragment length polymorphism.ResultsThe frequency of VDR-Taq I TT genotype in the case families was significantly higher than that in the control families (P < 0.05) , however, the frequency of VDR-Fok I CC genotype in the case families was significantly higher than that in the control families (P < 0.05). The frequency of family members carriying Taq I T-Fok I C haplotype in the case families was significantly higher than that in the control families (OR = 1.67, P < 0.05), however, the frequency of family members carrying Taq I C-Fok I T haplotype in the case families was significantly lower than that in the control families (OR = 0. 24, P < 0.05). The similar results were found in the familial biological kinship relatives with any HBV-infected makers.ConclusionVDR-Taq I and -Fok I gene polymorphisms are likely to play a substantial role in HBsAg familial aggregation.

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