• Eur Spine J · May 2012

    Comparative Study

    Diffusion-weighted MR imaging in differentiation between osteoporotic and neoplastic vertebral fractures.

    • G Pozzi, C Garcia Parra, P Stradiotti, T V Tien, A Luzzati, and A Zerbi.
    • IRCCS Istituto Ortopedico Galeazzi, via R. Galeazzi 3, Milan, Italy. graziapozzi@gmail.com
    • Eur Spine J. 2012 May 1;21 Suppl 1:S123-7.

    PurposeTo assess the usefulness of magnetic resonance imaging (MRI) with spin-echo echo-planar diffusion-weighted imaging (SE-EPI-DWI) in differentiation between vertebral osteoporotic fractures and pathological neoplastic fractures.Materials And MethodsThirty-three patients with both osteoporotic or neoplastic vertebral fractures diagnosed with X-ray or TC were studied with MRI exam, (1.5 T unit) with DWI sequences. DWI sequences were qualitatively analyzed. Apparent diffusion coefficient (ADC) values were also determined and compared to the definitive histologic diagnosis.ResultsDWI of neoplastic lesions showed hyperintensity signal in 22 out of 23 cases. Mean ADC value of neoplastic fractures was 1.241 ± 0.4 × 10(-3) mm(2)/s; mean ADC value of osteoporotic fractures was 0.646 ± 0.368 × 10(-3) mm(2)/s. Neoplastic fractures showed ADC values significantly higher than osteoporotic ones (p < 0.001). DWI imaging and histology showed a significant correlation.ConclusionDWI provides reliable information to support MRI diagnosis of neoplastic versus osteoporotic fractures. ADC value appears as a useful adjunctive parameter.

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