• J. Neurol. Neurosurg. Psychiatr. · Jan 2010

    Neuromyelitis optica-IgG (aquaporin-4) autoantibodies in immune mediated optic neuritis.

    • A Petzold, S Pittock, V Lennon, C Maggiore, B G Weinshenker, and G T Plant.
    • Department of Neuroinflammation, Institute of Neurology, University College London, London, UK. a.petzold@ion.ucl.ac.uk
    • J. Neurol. Neurosurg. Psychiatr. 2010 Jan 1; 81 (1): 109-11.

    AbstractThe clinical course of immune mediated optic neuritis (ON) will depend on the specific underlying inflammatory disease. These disorders have traditionally been classified according to clinical and MRI findings. Aquaporin-4 (AQP4) autoantibodies (neuromyelitis optica-IgG (NMO-IgG)) may have diagnostic and prognostic value in patients who present with isolated ON. In this prospective study, NMO-IgG was evaluated in 114 patients with ON in the following contexts: neuromyelitis optica (NMO), multiple sclerosis (MSON), chronic relapsing inflammatory ON (CRION), relapsing isolated ON (RION) and single isolated ON (SION). The proportion seropositive was 56% for NMO (n = 9), 0% for MSON (n = 28) and 5% for the remaining diagnostic categories (CRION (n = 19), RION (n = 17) and SION (n = 41)). Testing for NMO-IgG in patients with recurrent or severe ON who lack convincing evidence of MS may identify patients who would benefit from immunosuppression rather than MS directed immunomodulatory therapies.

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