• Cancers · Dec 2018

    Long-Term Outcome after Hemithyroidectomy for Papillary Thyroid Cancer: A Comparative Study and Review of the Literature.

    • Yossi Geron, Carlos Benbassat, Miriam Shteinshneider, Shlomit Koren, Keren Or, Efrat Markus, Dania Hirsch, and Muallem Kalmovich Limor L 0000-000... more 2-2328-6959 Sackler Faculty of Medicine, Tel-Aviv University, Ramat Aviv 69978, Tel-Aviv, Israel. Limormuallem@gmail. less
    • Endocrine Institute, Assaf Harofeh Medical Center, Zerifin 70300, Beer Ya'akov, Israel. yosgeron@gmail.com.
    • Cancers (Basel). 2018 Dec 27; 11 (1).

    AbstractBackground: The extent of surgery for differentiated thyroid cancer (DTC) remains a controversial issue. Since a less aggressive approach is becoming more predominant, we aim here to study the short- and long-term outcomes of DTC patients after hemithyroidectomy. Methods: From a total of 1252 consecutive papillary thyroid cancer (PTC) patients, 109 treated with hemithyroidectomy and 50 with total thyroidectomy but no I131 were included. Persistent or recurrent disease was defined based on histopathology, imaging studies, and thyroglobulin levels. Results: Our hemithyroidectomy cohort included females (84.4%), microcarcinomas (81.9%), TNM stage I (95.4%), and a low American Thyroid Association (ATA) recurrence risk (94.5%). At one-year post-treatment, 3.7% had persistent disease (all female, median age 55 years, tumor size 7.5 mm). Recurrent disease was detected in 7.5% of those with excellent response at 1-year. With a follow-up of 8.6 years (1⁻48), all 109 patients were disease free at last visit, including the 11 patients (10.1%) who received additional treatment. Also, when comparing the hemi- and total thyroidectomy groups no significant differences were found in the rate of persistent and recurrent disease, overall mortality, and disease status at last visit. Conclusions: For properly selected low-risk PTC patients, hemithyroidectomy is a safe treatment option with a favorable long-term outcome.

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