• Fasen Huang, Kai Sun, Xuyue Pan, Kunming Xie, Junde Wu, Jingwei Tao, Yufeng Ma, Yinze Qi, Zhanhua Ma, Xinyu Li, Huan Liang, Shulong Wang, Zhen Lei, and Zhaojun Chen.
• The Third Affiliated Hospital of Beijing University of Chinese Medicine.
• Medicine (Baltimore). 2019 Nov 1; 98 (46): e17905e17905.

BackgroundAnkle sprain is one of the most common musculoskeletal injuries in our daily life, which may lead to chronic ankle instability, reducing the quality of patients' life and imposing a heavy burden on social medical security system. There are many kinds of methods treating ankle sprain, which can be divided into the conservative treatments and surgical intervention. Acupuncture is one of the conservative treatments for ankle sprain, especially in China. Therefore, we perform a systematic review and meta-analysis to evaluate the evidence for acupuncture's effectiveness, safety and cost benefits for the treatment.MethodsFor the acquisition of required data of eligible randomized controlled trials (RCTs), literature search will be undertaken from the following database: PubMed, Embase, Web of Science, The Cochrane Library, Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov, Chinese National Knowledge Infrastructure (CNKI), VIP Database, and Wanfang database. Quality assessment of the included studies will be independently performed according to the Cochrane Risk of Bias Tool by 2 investigators and the level of evidence for results will be assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) method. Statistical analysis will be conducted with Revman 5.3.ResultsFrom the study we will assess the effectiveness, safety and cost benefit of acupuncture on pain relief and functional improvement in patients with ankle sprain.ConclusionThe conclusion of this study will provide evidence to ensure the effectiveness, safety and cost benefits of acupuncture on ankle sprain, which can further guide the selection of appropriate interventions.Prospero Registration NumberCRD42018116829.

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