• J Stroke Cerebrovasc Dis · Oct 2014

    Association of variants in KCNK17 gene with ischemic stroke and cerebral hemorrhage in a Chinese population.

    • Lingbin He, Qingfeng Ma, Yongqin Wang, Xin Liu, Yuan Yuan, Yongzhi Zhang, Wenjing Ou, Lisheng Liu, Xuerui Tan, and Xingyu Wang.
    • The First Affiliated Hospital, Medical College of Shantou University, Shantou, Guangdong, China; Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China.
    • J Stroke Cerebrovasc Dis. 2014 Oct 1; 23 (9): 2322-7.

    BackgroundKCNK17 (potassium channel, subfamily K, member17) has a role in the pathogenesis of stroke. We reported previously that rs10947803 single-nucleotide polymorphism (SNP) in KCNK17 is associated with cerebral hemorrhage in a Chinese population. The aim of the present study was to examine other SNPs in the KCNK17 gene that are associated with cerebral hemorrhage and other subtypes of stroke in the Chinese population.MethodsA total of 1356 subjects with stroke and 1225 control patients were examined by a case-control methodology. The SNPs (rs12214600, rs12195376, rs2758912, and rs10807204) in KCNK17 gene were genotyped with the TaqMan real-time polymerase chain reaction assay.Resultsrs12214600 SNP in KCNK17 was significantly associated with cerebral hemorrhage (unadjusted odds ratio = .55, 95% confidence interval = .35-.86, P = .008, q = .0328) under the allele model. After adjusting for age, sex, and hypertension, we found that the association remained significant (odds ratio = .56, 95% confidence interval = .35-.90, P = .0158). There was no association detected for other SNPs in KCNK17 with cerebral hemorrhage, and none of the SNPs in KCNK17 had an association with ischemic stroke.ConclusionsThe T carrier of an SNP (rs12214600) is associated with reduced risk of cerebral hemorrhage in the Chinese population, together with previous findings that SNPs rs10947803 and rs12214600 in the KCNK17 gene are associated with hemorrhagic stroke, but none of the SNPs tested had an association with ischemic stroke. KCNK17 may be important in the pathogenesis of cerebral hemorrhage.Copyright © 2014 National Stroke Association. Published by Elsevier Inc. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…