• Ji Young Bang, Shantel Hebert-Magee, Jessica Trevino, Jayapal Ramesh, and Shyam Varadarajulu.
• Division of Gastroenterology-Hepatology, University of Alabama at Birmingham, Birmingham, Alabama 35294-0007, USA.
• Gastrointest. Endosc. 2012 Aug 1; 76 (2): 321-7.

BackgroundTo overcome limitations of cytology, biopsy needles have been developed to procure histologic samples during EUS.ObjectiveTo compare 22-gauge (G) FNA and 22G biopsy needles (FNB) for EUS-guided sampling of solid pancreatic masses.DesignRandomized trial.SettingTertiary-care medical center.PatientsThis study involved 56 patients with solid pancreatic masses.InterventionSampling of pancreatic masses by using 22G FNA or 22G FNB devices.Main Outcome MeasurementsCompare the median number of passes required to establish the diagnosis, diagnostic sufficiency, technical performance, complication rates, procurement of the histologic core, and quality of the histologic specimen.ResultsA total of 28 patients were randomized to the FNA group and 28 to the FNB group. There was no significant difference in median number of passes required to establish the diagnosis (1 [interquartile range 1-2.5] vs 1 [interquartile range 1-1]; P = .21), rates of diagnostic sufficiency (100% vs 89.3%; P = .24), technical failure (0 vs 3.6%; P = 1.0), or complications (3.6% for both) between FNA and FNB needles, respectively. Patients in whom diagnosis was established in passes 1, 2, and 3 were 64.3% versus 67.9%, 10.7% versus 17.9%, and 25% versus 3.6%, respectively, for FNA and FNB cohorts. There was no significant difference in procurement of the histologic core (100% vs 83.3%; P = .26) or the presence of diagnostic histologic specimens (66.7% vs 80%; P = .66) between FNA and FNB cohorts, respectively.LimitationsOnly pancreatic masses were evaluated.ConclusionDiagnostic sufficiency, technical performance, and safety profiles of FNA and FNB needles are comparable. There was no significant difference in yield or quality of the histologic core between the 2 needle types.Copyright © 2012 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.

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