• Hayes R Faculty of Medicine, Dalhousie University, Canada., Cummings B, Miller RA, and Guha AK.
• Faculty of Medicine, Dalhousie University, Canada.
• J Cutan Med Surg. 2000 Oct 1; 4 (4): 208-12.

BackgroundPaget's disease is an extremely rare condition of the male breast that presents as an eczematous change of the nipple and areola. It is almost always associated with an underlying intraductal carcinoma.ObjectiveA case of Paget's disease of the male breast with extension into adnexal structures is reported.Materials And MethodsA MEDLINE search for cases of Paget's disease of the male breast was performed and the cases were reviewed. The following antibodies were used in immunohistochemical staining: Rabbit Anti-Human c-erbB-2 Oncoprotein, monoclonal Mouse Anti-Human Estrogen Receptor (IgG1, kappa), and monoclonal Mouse Anti-Human Progesterone Receptor (Clone PgR 636).ResultsThis is only the 43rd histologically proven case of Paget's disease of the male breast in the world literature and, to our knowledge, the first to document extension of Paget's cells into adnexal structures, including eccrine glands.ConclusionMammary Paget's disease is a rare phenomenon among men.

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