• Ethics & human research · Jul 2020

    Why Challenge Trials of SARS-CoV-2 Vaccines Could Be Ethical Despite Risk of Severe Adverse Events.

    • Nir Eyal.
    • Directs the Center for Population-Level Bioethics at Rutgers University and is the Henry Rutgers professor of bioethics in the Department of Health Behavior, Society and Policy at Rutgers School of Public Health and in the Department of Philosophy at Rutgers's School of Arts and Sciences.
    • Ethics Hum Res. 2020 Jul 1; 42 (4): 24-34.

    AbstractHuman challenge trials to test the efficacy of vaccine candidates against SARS-CoV-2, the novel coronavirus behind Covid-19, could save considerable time and many lives. But they may initially seem unethical because they expose healthy volunteers to a live virus that is killing many people and for which no cure exists. This article argues that this is not the correct test of their ethics. The correct test is comparative. And in the special circumstances of the Covid-19 pandemic, human challenge trials meet the correct test better than standard efficacy testing would.© 2020 by The Hastings Center. All rights reserved.

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