• Eur. J. Cancer · Sep 2020

    Could anti-CD20 therapy jeopardise the efficacy of a SARS-CoV-2 vaccine?

    • Roch Houot, Ronald Levy, Guillaume Cartron, and Philippe Armand.
    • Department of Hematology, CHU Rennes, University of Rennes, INSERM U1236, Rennes, France; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: roch.houot@chu-rennes.fr.
    • Eur. J. Cancer. 2020 Sep 1; 136: 4-6.

    AbstractA vaccine against SARS-CoV-2 might represent the most promising approach to halt durably the current COVID-19 pandemic. We believe that anti-CD20 therapy may jeopardise the efficacy of such a vaccine. This is regrettable because patients receiving anti-CD20 therapy (i.e. those with haematologic malignancies or autoimmune disorders) are particularly at risk of severe COVID-19 and, as such, are the most in need of a vaccine. Here, we review the reasons why anti-CD20 therapy may abrogate or diminish the efficacy of a vaccine against SARS-CoV-2 and we draw physicians' attention towards this potential risk so that it can be considered when evaluating the risk/benefit ratio of anti-CD20 therapy during the current pandemic.Copyright © 2020 Elsevier Ltd. All rights reserved.

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