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J. Cardiovasc. Pharmacol. · Mar 2017
ReviewHypertension's 3 Dilemmas and 3 Solutions: Pharmacology of the Kidney in Hypertension.
- William A Pettinger.
- Division of Clinical Pharmacology (Retired), University of Texas Southwestern Medical School (Retired), Bonita Springs, FL.
- J. Cardiovasc. Pharmacol. 2017 Mar 1; 69 (3): 129-139.
AbstractThe Hypertension Community has 3 conflicting dilemmas: a goal systolic pressure of 120 mm Hg or less (the SPRINT Trials), 40% of our 60,000,000 hypertensives still sustain blood pressures above 140/90 mm Hg, and our most potent antihypertensive drug minoxidil sits on the sidelines, imprisoned in the Food and Drug Administration's Black Box designation. My solutions to these dilemmas are: (1) review of the facts of our most potent antihypertensive drug minoxidil which is essentially free of toxicity, (2) treatment focus on the fundamental cause of high blood pressure, that is excess dietary sodium and, (3) prevention of, and/or reversal of, the fundamental mechanism of worsening hypertension, arteriolar hypertrophy.
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