• Mitra Mehrad, Thomas V Colby, Giulio Rossi, and Alberto Cavazza.
• From the Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee (Mehrad).
• Arch. Pathol. Lab. Med. 2020 Dec 1; 144 (12): 1501-1508.

Context.—Transbronchial cryobiopsy is an emerging procedure to obtain lung tissue for diagnosis of interstitial lung disease and has gained popularity because it is less invasive and has a lower rate of complications compared with nonselective surgical lung biopsy.Objective.—To provide an overview of the status of the medical literature regarding transbronchial cryobiopsy.Data Sources.—A literature search was performed using PubMed search engine. The terms "cryobiopsy" or "cryoprobe" and "interstitial lung disease" or "diffuse parenchymal lung disease" or "pulmonary fibrosis" were used, with the search concluding at the end of November 2019.Conclusions.—While the diagnostic yield of transbronchial cryobiopsy is slightly lower than surgical lung biopsy, a growing amount of literature suggests that with a multidisciplinary approach cryobiopsy provides diagnostic and prognostic information approaching that of surgical lung biopsy with lower morbidity and mortality.© 2020 College of American Pathologists.

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