• Chao Zhang, Jun-Yi Wu, Dong-Lai Deng, Bing-Yang He, Yuan Tao, Yu-Ming Niu, and Mo-Hong Deng.
• Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, South Renmin Road, Shiyan, China.
• Oncotarget. 2016 Dec 20; 7 (51): 84043-84053.

AbstractTemporomandibular disorders (TMD) are a group of clinical problems affecting temporomandibular joint (TMJ), myofascial muscles and other related structures. Splint therapy is the most commonly used approach to treatment of TMD, but its effectiveness is remains unclear. We therefore conducted a meta-analysis to evaluate the effectiveness of splint therapy for TMD in adults. The electronic databases PubMed, EMBASE, Cochrane Library, and ClinicalTrials.gov were searched for reports published up to March 31, 2016. Thirteen eligible studies involving 538 patients were identified. The results indicated that splint therapy increased maximal mouth opening (MMO) for patients with a MMO <45mm and reduced pain intensity measured using the visual analogue scale (VAS) for patients with TMD without specific description (TMDSD). Splint therapy also reduced the frequency of painful episodes for patients with TMJ clicking. No publication bias was observed, as determined with Egger's test for all outcomes. On the basis of this evidence, we recommend the use of splints for the treatment and control of TMD in adults.

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