• Expert Opin Drug Saf · Nov 2002

    Editorial Review

    Zyban-- is there a cause for concern?

    • Joseph A Tracey.
    • Expert Opin Drug Saf. 2002 Nov 1; 1 (4): 303-5.

    AbstractBupropion hydrochloride is a monocyclic antidepressant which is used in a slow-release formulation as a smoking cessation aid. Its side effects include insomnia and dry mouth with seizures occurring in 1 in 1000 patients. In overdose, it can cause tachycardia, conduction defects and convulsions. It is, however, effective in smoking cessation in approximately 20% of patients and may be more effective if combined with nicotine replacement therapy. The key question is whether the risks associated with the drug are justified by the obvious benefits to health from smoking cessation.

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