• Eur Spine J · Dec 2012

    Etanercept treatment enhances clinical and neuroelectrophysiological recovery in partial spinal cord injury.

    • Fatih Bayrakli, Hatice Balaban, Unal Ozum, Cevdet Duger, Suat Topaktas, and Hamit Zafer Kars.
    • Department of Neurosurgery, Cumhuriyet University School of Medicine, Sivas 58140, Turkey. fbayrakli@hotmail.com
    • Eur Spine J. 2012 Dec 1;21(12):2588-93.

    PurposeTo investigate the effect of an anti-TNF-α agent (etanercept) on recovery processes in a partial spinal cord injury (SCI) model using clinical and electrophysiological tests.MethodsTwenty-four New Zealand rabbits were divided into three groups: group 1 [SCI + 2 ml saline intramuscular (i.m.), n = 8], group 2 (SCI + 2.5 mg/kg etanercept, i.m., 2-4 h after SCI, n = 8) and group 3 (SCI + 2.5 mg/kg etanercept, i.m., 12-24 h after SCI, n = 8). Rabbits were evaluated before SCI, immediately after SCI, 1 week after, and 2 weeks after SCI, clinically by Tarlov scale and electrophysiologically by SEP.ResultsTarlov scores of groups 2 and 3 were significantly better than group 1, 2 weeks after SCI. SEP recovery was significantly better in groups 2 and 3 than group 1, 2 weeks after SCI.ConclusionsThese results show that blocking TNF-α mediated inflammation pathway by an anti-TNF-α agent enhances clinical and electrophysiological recovery processes in partial SCI model.

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