• Vijitha S Vempuluru, Anasua Ganguly, and Swathi Kaliki.
• Operation Eyesight Universal Institute for Eye Cancer (VSV, SK), L V Prasad Eye Institute, Hyderabad, India.
• Curr. Eye Res. 2021 Apr 28.

PurposeTo describe the clinical features and management of post-keratoplasty ocular surface squamous neoplasia (pk-OSSN) in patients with xeroderma pigmentosum (XP).MethodsRetrospective case series of 7 patients with XP.ResultsThe mean age at diagnosis of pk-OSSN was 22 years (median, 21 years; range, 12 to 37 years). There were 4 males and 3 females. Full thickness keratoplasty (n=5) and Descemet stripping endothelial keratoplasty (n=2) were performed for optical (n=6) and therapeutic indications (n=1). None of the patients had evidence of OSSN before or at the time of keratoplasty. Mean interval between keratoplasty and pk-OSSN was 44 months (median, 14 months; range, 3 to 109 months). Tumor epicenter was located at the limbus (n=4), bulbar conjunctiva (n=1) or cornea (n=2). Mean dimension of the lesions was 12 mm (median, 11 mm; range, 6 to 18 mm). Treatment details included conjunctival/corneal tumor excision (n=6), plaque brachytherapy (n=3; 1 primary, 2 adjuvant) and extended enucleation (n=1). One patient had tumor recurrence 18 months after OSSN treatment, which was treated with wide excisional biopsy. All patients are alive and free of disease over a mean follow-up period of 37 months (median, 37 months; range, 4 to 65 months).ConclusionXP patients undergoing keratoplasty can develop OSSN several months to years after keratoplasty and require close follow-up for the same. Wide excisional biopsy with/without plaque radiotherapy is effective in the management of pk-OSSN.

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