• J. Cutan. Pathol. · Nov 1999

    Case Reports

    In vivo abnormal keratinazation in Darier-White's disease as viewed by real-time confocal imaging.

    • S González, G Rubinstein, V Mordovtseva, M Rajadhyaksha, and R R Anderson.
    • Dermatology Department, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA. gonzalsa@helix.mgh.harvard.edu
    • J. Cutan. Pathol. 1999 Nov 1; 26 (10): 504-8.

    AbstractDarier-White's disease is a rare autosomal-dominant disorder of keratinization. The underlying pathology for the clinical presentation is acantholysis, and various types of dyskeratosis and acanthosis. In this study, we utilized a non-invasive optical imaging modality, confocal reflectance microscopy, to identify specific histologic features of Darier-White's disease in vivo. Micrographic findings in the confocal images were corps ronds, suprabasal clefts, acantholytic suprabasal keratinocytes, and villi. Real-time confocal images are illustrative and can be well correlated with known light microscopic phenomena, particularly in the case of keratinization abnormalities in Darier-White's disease.

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