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- X L Zhu, Danny T M Chan, Claire K Y Lau, Wai S Poon, Vincent C T Mok, Anne Y Y Chan, Lawrence K S Wong, Jonas H M Yeung, Michael C M Leung, Venus Y H Tang, Rosanna K M Wong, and Carol Yeung.
- Division of Neurosurgery, Department of Surgery, Alice Ho Miu Ling Nethersole Hospital, Hong Kong Special Administrative Region, Hong Kong.
- World Neurosurg. 2014 Dec 1;82(6):987-93.
BackgroundDeep brain stimulation (DBS) is an effective but costly treatment for patients with advanced Parkinson disease (PD). This study examined the cost-effectiveness of DBS in relation to its improved effectiveness to help funding decision makers decide whether the treatment should be adopted. The incremental cost-effective ratio (ICER) per quality-adjusted life year has been benchmarked as being between US$50,000 and US$100,000 by US agencies, whereas it is less than €30,000 per quality-adjusted life year in Europe.ObjectiveTo provide cost-effectiveness information of subthalamic nucleus DBS for patients with advanced PD.MaterialsDirect medical expenses during the year before the DBS treatment were used to measure the baseline cost. Cost-effectiveness was measured by the ICER for the Unified Parkinson's Disease Rating Scale Part III and the ICER for the EuroQol Group's Health-Related Quality of Life measurement.ResultsThirteen patients with advanced PD were recruited between January 2009 and January 2011. A 1-point improvement in the Unified Parkinson's Disease Rating Scale Part III score was associated with an ICER of US$926 in the first year and US$421 in the second year. A 1-point improvement on the EuroQol Group's Health-Related Quality of Life measurement was associated with an ICER of US$123,110 in the first year and US$62,846 in the second year.ConclusionCost-effectiveness of subthalamic nucleus DBS for treatment of advanced PD is greater during a 2-year period than 1 year only. These results can be used as a reference for the use of DBS for PD in a region with public health financing.Copyright © 2014 Elsevier Inc. All rights reserved.
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