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- Erin R Hascup and Kevin N Hascup.
- Department of Neurology, Center for Alzheimer's Disease and Related Disorders Department of Pharmacology, Neurosciences Institute, P.O. Box 19628, Springfield, IL, 62794-9628, USA.
- Geroscience. 2020 Aug 1; 42 (4): 1083-1087.
AbstractThe current pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has created an unparalleled health crisis. Besides the acute respiratory infection, CoVs are neuroinvasive causing additional inflammation and neurodegeneration. This is likely also true of SARS-CoV-2 given reports of neurological manifestations in coronavirus disease 2019 (COVID-19) positive patients. Older adults > 65 years of age constitute a high-risk group prone to severe infection and death. Despite the higher mortality rate, a majority of cases are expected to recover and survive from this viral outbreak. But, the long-term consequences of SARS-CoV-2 neuroinfection are unknown. We discuss these potential chronic changes to the central nervous system (CNS) in relation to accelerated brain aging and age-related neurodegenerative disorders.
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