• Gang-Qun Wu, Xiao-Min Chou, Wen-Jian Ji, Xiao-Gang Yang, Luo-Xin Lan, Yan-Jun Sheng, Yang-Fang Shen, Jian-Rong Li, Guo-Zhong Huang, Wen-Hua Yu, Xiao-Qiao Dong, Quan Du, Ding-Bo Yang, Zu-Yong Zhang, Hao Wang, Yong-Feng Shen, and Li Jiang.
• Department of Neurosurgery, The Tonglu TCM Hospital, 25 Guangchang Road, Tonglu 311500, China. Electronic address: huauna@126.com.
• Clin. Chim. Acta. 2016 Jul 1; 458: 124-8.

BackgroundNesfatin-1 is related to inflammation. Its increased circulating concentrations are associated with the severity and prognosis of subarachnoid hemorrhage. In-hospital major adverse events (IMAEs), including acute traumatic coagulopathy, progressive hemorrhagic injury and posttraumatic cerebral infarction, are correlated with mortality after traumatic brain injury (TBI). The present study was designed to investigate the changes of plasma nesfatin-1 concentrations and further assess its association with inflammation, trauma severity, in-hospital mortality and IMAEs following TBI.MethodsWe measured plasma nesfatin-1 concentrations of 100 severe TBI patients and 100 controls. Progressive hemorrhagic injury and posttraumatic cerebral infarction were diagnosed based on a follow-up computerized tomography scan. Acute traumatic coagulopathy was identified according to a coagulation test.ResultsPlasma nesfatin-1 concentrations were significantly higher in patients than in controls and associated highly with Glasgow coma scale (GCS) scores and plasma C-reactive protein concentrations. Nesfatin-1 was indicated as an independent predictor for in-hospital mortality and IMAEs. In accordance with area under receiver operating characteristic curve, its predictive value was similar to GCS scores.ConclusionIncreased plasma nesfatin-1 concentrations are associated closely with inflammation, trauma severity and clinical outcomes, indicating that nesfatin-1 might be involved in inflammation and become a good prognostic biomarker following TBI.Copyright © 2016 Elsevier B.V. All rights reserved.

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