• J J Ronco, A Belzberg, P T Phang, K R Walley, P M Dodek, and J A Russell.
• Department of Pulmonary Research Laboratory, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
• Crit. Care Med. 1994 May 1; 22 (5): 777-82.

ObjectiveTo determine whether there are differences in hemodynamics, ventricular function, oxygen delivery, and oxygen consumption between septic and nonseptic patients who have the adult respiratory distress syndrome (ARDS).DesignCohort analytic study.SettingTertiary care medical and surgical intensive care unit, university hospital.PatientsEighteen septic (survivors, n = 8; nonsurvivors, n = 10) and 14 nonseptic (survivors, n = 7; nonsurvivors, n = 7) patients studied within 24 hrs of the diagnosis of ARDS.InterventionsSimultaneous hemodynamic, radionuclide cineangiographic, and oxygen delivery and consumption measurements.Measurements And Main ResultsCardiac index, right and left ventricular ejection fractions, end-diastolic volume indices, oxygen delivery, and oxygen consumption were measured. There were no differences in mean systemic and pulmonary arterial pressures, cardiac index, systemic vascular resistance, right and left ventricular ejection fractions, end-diastolic volumes, and oxygen delivery and consumption between septic and nonseptic patients.ConclusionsEarly in the course of ARDS, there were no differences in hemodynamics, ventricular function, and oxygen delivery and consumption between septic and nonseptic patients. Sepsis does not account for the previously reported differences in hemodynamics, ventricular function, and oxygen delivery and oxygen consumption between survivors and non-survivors of ARDS. We speculate that both ARDS and sepsis cause release of mediators which cause similar changes in hemodynamics, ventricular function, and oxygen delivery and consumption.

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