• Eurosurveillance · Aug 2020

    Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020.

    • Anika Singanayagam, Monika Patel, Andre Charlett, Jamie Lopez Bernal, Vanessa Saliba, Joanna Ellis, Shamez Ladhani, Maria Zambon, and Robin Gopal.
    • These authors contributed equally.
    • Eurosurveillance. 2020 Aug 1; 25 (32).

    AbstractSevere acute respiratory syndrome coronavirus 2 viral load in the upper respiratory tract peaks around symptom onset and infectious virus persists for 10 days in mild-to-moderate coronavirus disease (n = 324 samples analysed). RT-PCR cycle threshold (Ct) values correlate strongly with cultivable virus. Probability of culturing virus declines to 8% in samples with Ct > 35 and to 6% 10 days after onset; it is similar in asymptomatic and symptomatic persons. Asymptomatic persons represent a source of transmissible virus.

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