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- Jeroen Hoogland, Judith A Boel, de Bie Rob M A RMA Department of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Ben A Schmand, Ronald B Geskus, John C Dalrymple-Alford, Connie Marras, Charles H Adler, Daniel Weintraub, Carmen Junque, Kenn F Pedersen, Brit Mollenhauer, Jennifer G Goldman, Alexander I Tröster, David J Burn, Irene Litvan, Gert J Geurtsen, and MDS Study Group “Validation of Mild Cognitive Impairment in Parkinson Disease”.
- Department of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
- Mov. Disord. 2019 Mar 1; 34 (3): 430-435.
BackgroundThe International Parkinson and Movement Disorders Society criteria for mild cognitive impairment in PD need validation. The objectives of this present study were to evaluate prognostic validity of level I (abbreviated) International Parkinson and Movement Disorders Society mild cognitive impairment in PD criteria for development of PD dementia and compared them with level II (comprehensive) criteria.MethodsWe analyzed data from 8 international studies (1045 patients) from our consortium that included baseline data on demographics, motor signs, depression, detailed neuropsychological testing, and longitudinal follow-up for conversion to Parkinson's disease dementia. Survival analysis evaluated their contribution to the hazard of Parkinson's disease dementia.ResultsLevel I mild cognitive impairment in PD, increasing age, male sex, and severity of PD motor signs independently increased the hazard of Parkinson's disease dementia. Level I and level II mild cognitive impairment in PD classification had similar discriminative ability with respect to the time to Parkinson's disease dementia.ConclusionsLevel I mild cognitive impairment in PD classification independently contributes to the hazard of Parkinson's disease dementia. This finding supports the prognostic validity of the abbreviated mild cognitive impairment in PD criteria. © 2019 International Parkinson and Movement Disorder Society.© 2019 International Parkinson and Movement Disorder Society.
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