• L Dade Lunsford, Ajay Niranjan, Hideyuki Kano, and Douglas Kondziolka.
• Department of Neurological Surgery and Center for Image-Guided Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. lunsfordld@upmc.edu
• Prog Neurol Surg. 2013 Jan 1; 27: 22-34.

AbstractGamma Knife stereotactic radiosurgery was first applied for the treatment of an intracranial arteriovenous malformation (AVM) in 1968. Using biplane angiography to target a small-volume, deep-seated lesion, photons were cross-fired on the pathological shunt. The AVM was obliterated within 3 years. This began a cautious introduction of Gamma Knife radiosurgery in the 1970s. As the Gamma Knife technology spread to sites in Europe, South America and the USA in the 1980s, AVM radiosurgery became a primary indication. During the early years the usual standard was to deliver a single radiosurgical isocenter to the target defined by 2-dimensional angiography. Most patients had small-volume AVMs unsuitable for surgical excision. Over time the technique of Gamma Knife AVM surgery evolved to include: careful patient selection, discussion of appropriate treatment strategies, anticonvulsant administration for lobar locations and intraoperative targeting using both high-resolution axial plane imaging--usually magnetic resonance imaging--coupled with biplane digital subtraction angiography. High-speed computer dose planning integrated with more detailed imaging strategies facilitated conformal radiation delivery in a single treatment session coupled with high selectivity of the dose delivered. Multiple isocenters became routine. Long-term follow-up care included serial imaging evaluations to assess the response and to detect complications. Imaging was critical to confirm the desired radiobiological response--complete obliteration. Long-term follow-up after obliteration confirmed that AVM radiosurgery had a high success rate for properly selected patients and a risk-benefit profile that substantiated patient safety. Twenty-year results after Gamma Knife radiosurgery for AVMs are currently available. Established roles have been found for pediatric cases and for larger-volume AVMs unsuitable for surgical removal. The role and technique of embolization prior to radiosurgery continue to be evaluated. Current dose response data based on volume and predictions of adverse radiation effects guide current care.Copyright © 2013 S. Karger AG, Basel.

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