• van Deursen Anna M M AMM Julius Center for Health Sciences and Primary Care. Department of Immunology, W, Marlies A van Houten, Chris Webber, Michael Patton, Daniel A Scott, Scott Patterson, Mohinder Sidhu, Wayne Drews, William C Gruber, Emilio A Emini, Diederick E Grobbee, Bonten Marc J M MJM Julius Center for Health Sciences and Primary Care. Department of Medical Microbiolo, and Sanders Elisabeth A M EAM Department of Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht..
• Julius Center for Health Sciences and Primary Care.
• Clin. Infect. Dis. 2017 Sep 1; 65 (5): 787-795.

BackgroundIn the randomized controlled Community-Acquired Pneumonia Immunization Trial in Adults (CAPiTA), the efficacy of the 13-valent pneumococcal conjugate vaccine (PCV13) against first episodes of vaccine-type community-acquired pneumonia in adults aged ≥65 years was 46%. The long-term immunogenicity of PCV13 in pneumococcal vaccine-naive older adults was investigated as part of CAPiTA.MethodsWe determined the immune responses to PCV13 before and at 1, 12, and 24 months after vaccination in 1006 PCV13 recipients and 1005 controls with 3 age-stratified study participant cohorts. PCV13 serotype-specific opsonophagocytic activity (OPA) titers and immunoglobulin G (IgG) concentrations were determined.ResultsSample collection completeness was at least 93.4% at each time point. In all 3 age categories, a single dose of PCV13 elicited OPA titers and IgG concentrations for all 13 serotypes that were significantly higher than baseline and the corresponding responses in the placebo group at all time points. In the eldest subjects (≥80 years of age at vaccination), OPA titers and IgG concentrations remained above baseline and there was no apparent difference in OPA titers and IgG concentrations between those with self-reported comorbidities and healthy older adults. However, the study was not powered to determine statistical significance between different age and comorbidity groups, and thus these results are exploratory.ConclusionsIn immunocompetent adults ≥65 years of age, PCV13 elicits significant increases in OPA titers and IgG concentrations that persist 2 years postvaccination for all 13 serotypes, regardless of age and comorbidity.Clinical Trials RegistrationNCT00744263.© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

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