• Magn Reson Med · Dec 2002

    Application of sensitivity-encoded echo-planar imaging for blood oxygen level-dependent functional brain imaging.

    • Jacco A de Zwart, Peter van Gelderen, Peter Kellman, and Jeff H Duyn.
    • Advanced MRI, Laboratory of Functional and Molecular Imaging, NINDS, National Institutes of Health, Bethesda, Maryland 20892-1065, USA. Jacco.deZwart@nih.gov
    • Magn Reson Med. 2002 Dec 1; 48 (6): 1011-20.

    AbstractThe benefits of sensitivity-encoded (SENSE) echo-planar imaging (EPI) for functional MRI (fMRI) based on blood oxygen level-dependent (BOLD) contrast were quantitatively investigated at 1.5 T. For experiments with 3.4 x 3.4 x 4.0 mm(3) resolution, SENSE allowed the single-shot EPI image acquisition duration to be shortened from 24.1 to 12.4 ms, resulting in a reduced sensitivity to geometric distortions and T(*)(2) blurring. Finger-tapping fMRI experiments, performed on eight normal volunteers, showed an overall 18% loss in t-score in the activated area, which was substantially smaller than expected based on the image signal-to-noise ratio (SNR) and g-factor, but similar to the loss predicted by a model that takes physiologic noise into account.

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