• Young-Chang P Arai, Izumi Makino, Shuichi Aono, Hiromichi Yasui, Hideya Isai, Makoto Nishihara, Noboru Hatakeyama, Takashi Kawai, Tatsunori Ikemoto, Shinsuke Inoue, and Takahiro Ushida.
• Multidisciplinary Pain Center, School of Medicine, Aichi Medical University, Aichi 480-1195, Japan.
• Evid Based Compl Alt. 2015 Jan 1; 2015: 750345.

AbstractThere are patients who suffer from persistent dentoalveolar pain disorder (PDAP) which is a pain of the teeth, either dentoalveolar pain or nonodontogenic toothache, and its cause has not yet been identified. An effective intervention for PDAP has not yet been established. Interventions for patients with PDAP are generally pharmacological treatments such as antidepressants, anticonvulsants, and pregabalin. However, these medicines are not always effective for patients. The pain disorder in the orofacial region including temporomandibular disorder (TMD) and PDAP was effectively treated with our original exercise therapy. However, we did observe some intractable cases of PDAP even when our original exercise therapy was used. This paper presents our findings in which Kamishoyosan improved the pain intensity in 14 out of 15 PDAP patients refractory to our original exercise therapy.

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